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Alterations in intestinal bacterial composition can increase intestinal permeability, which is associated with elevated levels of zonulin, a protein that regulates cell communication

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In 3-week-old mice, the incidence of BAPN-induced aortic aneurysm and dissection (AAD) was 91.67%, and the mortality due to dissection rupture was 66.67% after BAPN treated for 3 weeks (Figure 2B and 2C)